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Precision Where Biology Demands It
Closely related protein isoforms can perform fundamentally different biological functions, yet their high structural similarity makes selective drug development challenging.
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Agneya BioSciences is developing a new approach to this problem by identifying non-conserved, chemically addressable regions that distinguish disease-driving protein isoforms from closely related family members.
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We use these differences to design precision covalent therapeutics with the goal of achieving greater molecular selectivity while preserving the function of closely related proteins
Target Identification
Discover non-conserved residues and structural microenvironments that distinguish disease-driving protein isoforms
Covalent Bonding
Use structure-based and computational drug discovery to create molecules capable of selective covalent engagement
Targeted Therapy
Advance the most promising compounds through biochemical, cellular and translational proof-of-concept
ISOFORM-SPECIFIC TARGETING • COVALENT DRUG DESIGN • PRECISION MEDICINE
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